Patient enrollment in medical trials: Selection bias in a randomized experiment

A-Tier
Journal: Journal of Econometrics
Year: 2008
Volume: 144
Issue: 2
Pages: 341-351

Score contribution per author:

4.022 = (α=2.01 / 1 authors) × 2.0x A-tier

α: calibrated so average coauthorship-adjusted count equals average raw count

Abstract

Self-selection can bias estimates of treatment effects from randomized experiments if one is interested in extrapolating results to the general population. This paper notes that there is an isomorphism between the Roy model for the sorting of workers into sectors and the decision of subjects to participate in randomized experiments. The main implication is that, as the probability of receiving active treatment rises, patients who are less optimistic about new treatment will begin to enroll and estimates of treatment effects will fall. This, in turn, implies that selection bias is positive. These findings are confirmed with data from trials of ulcer medications.

Technical Details

RePEc Handle
repec:eee:econom:v:144:y:2008:i:2:p:341-351
Journal Field
Econometrics
Author Count
1
Added to Database
2026-01-26