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Control of livestock disease had large spillover effects on human health. By 1900 the United States was a leader in livestock disease control, thanks to the efforts of the Bureau of Animal Industry. Its first chief, Daniel Salmon, established a model that would be copied around the world in campaigns against human and animal diseases. For the most part, the Progressive Era regulations to advance livestock health and food safety were spectacular successes. The bureau's main blunder was its failure to deal effectively with trichinosis, which was far more widespread than generally believed.