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The world faces formidable, but manageable, challenges in achieving food security in a world growing beyond 9 billion people in the coming decades. Five big challenges will necessitate shifting innovation strategy to place greater emphasis on sustainable increases in diet quality, on total factor productivity ‐ not just crop yield ‐ growth, on social protection programs, on Africa, on post‐farmgate agri‐food value chains, on risk management, and on reducing the land and water footprint of food production. We must be progressive in both senses of the term, having faith in science as an engine of societal advance, and standing with marginalized populations.